Advanced Synthetic Methodologies

Explore breakthrough research articles, reaction mechanisms, and innovative strategies in organic synthesis.

Research Articles

The Unsung Heroes of Catalysis: How Nitrogen Donors Power Molecular Transformations

Exploring the crucial role of nitrogen donor ligands in organometallic chemistry and homogeneous catalysis for sustainable molecular transformations.

Christian Bailey
Aug 10, 2025

The Copper Key: Unlocking Smarter Sulfonamide Drug Synthesis

Exploring copper-catalyzed methods for efficient synthesis of N,N-dialkylformamide sulfonamides in pharmaceutical manufacturing

Charlotte Hughes
Aug 10, 2025

The Radical Makeover: How Ruthenium Gave New Life to a Classic Reaction

Discover how ruthenium catalysts transformed the classic Barton-McCombie reaction through a pseudoreversible radical pathway, enabling efficient O-to-S alkyl migrations.

Charles Brooks
Aug 10, 2025

The Dance of Danger and Discovery: Azodicarboxylates in Organic Synthesis

Exploring the dual nature of azodicarboxylates in organic synthesis - from explosive hazards to powerful tools for drug development and green chemistry.

Levi James
Aug 10, 2025

The Green Chemistry Revolution: How Hypervalent Iodine Reagents Are Transforming Molecular Synthesis

Explore how hypervalent iodine(III) reagents are revolutionizing sustainable chemistry with their unique reactivity and environmental benefits.

Lily Turner
Aug 10, 2025

The Molecular Masterpiece: How Chemists Engineered Captopril, the First Oral ACE Inhibitor

Discover the chemical artistry behind captopril's synthesis, the first oral ACE inhibitor derived from snake venom, and its impact on hypertension treatment.

Lucas Price
Aug 10, 2025

Molecular Origami: The Art and Science of Crafting Azonia Aromatic Pentacycles

Breakthrough in synthesizing pentacyclic azonia systems with a rare 6-6-6-5-6 ring fusion pattern through one-pot tandem synthesis.

Thomas Carter
Aug 10, 2025

Sugar Coating and Cellular Switches: How Barbara Imperiali Illuminates Life's Molecular Machinery

Profile of Barbara Imperiali, a pioneer in chemical biology whose work on protein glycosylation and kinase signaling has transformed our understanding of molecular processes.

Sofia Henderson
Aug 10, 2025

The Silent Symphony: How Inorganic Reactions Conduct Our Material World

Exploring the fundamental inorganic reactions that shape our material world, from substitution to redox reactions, and their modern applications.

Julian Foster
Aug 10, 2025

The Silent Alchemists: How Atomic Tweaks Transform Air and Molecules

Exploring how heteroatom tuning of Criegee intermediates revolutionizes atmospheric chemistry and chemical synthesis

Lily Turner
Aug 10, 2025

Popular Articles