Research Articles
Bioorthogonal Chemistry for In Vivo Imaging: Advances in Precision Diagnostics and Future Frontiers
This comprehensive review explores the transformative role of bioorthogonal chemistry in advancing in vivo imaging for biomedical research and therapeutic development.
Virtual Screening in Drug Discovery: A 2025 Guide to Methods, Applications, and Best Practices
This article provides a comprehensive overview of virtual screening (VS) as a cornerstone computational technique in modern drug discovery.
DeePEST-OS: Accelerating Transition State Search in Organic Synthesis with Machine Learning
This article explores DeePEST-OS, a generic machine learning potential designed to overcome the computational bottleneck of traditional Density Functional Theory (DFT) in transition state searches for organic synthesis and drug...
AI-Driven Drug Synthesis: Machine Learning for Predicting Reaction Yields and Optimizing Conditions
This article provides a comprehensive overview of the transformative role of Machine Learning (ML) and Deep Learning (DL) in predicting chemical reaction yields and optimizing synthesis conditions for drug development.
Mechanochemical Milling: A Solvent-Free Synthesis Revolution for Pharmaceutical and Materials Science
This article provides a comprehensive exploration of mechanochemical milling as a sustainable, solvent-free paradigm for chemical synthesis.
Microwave-Assisted Organic Synthesis: Enhancing Reaction Yields and Efficiency in Drug Development
This article explores the transformative impact of Microwave-Assisted Organic Synthesis (MAOS) as a green and efficient methodology for chemical research and drug development.
Revolutionizing Reaction Discovery: How High-Throughput Experimentation and AI Are Accelerating Chemical Research
This article explores the transformative impact of High-Throughput Experimentation (HTE) on reaction discovery and optimization in chemical and pharmaceutical research.
Chemoenzymatic Synthesis of Natural Products: Integrating Biocatalysis and Organic Chemistry for Drug Discovery
This article comprehensively reviews the burgeoning field of chemoenzymatic synthesis and its transformative impact on natural product research and drug development.
Beyond the Canonical 20: Harnessing Non-Canonical Amino Acids for Next-Generation Therapeutics and Sustainable Synthesis
This article explores the transformative role of non-canonical amino acids (ncAAs) in advancing peptide-based drug discovery and synthesis.
Automating Synthesis Planning: A Guide to Data Extraction from Chemical Patents
This article provides a comprehensive overview of modern techniques for extracting chemical reaction data from patent documents to power synthesis planning and computer-aided drug discovery.