Advanced Synthetic Methodologies

Explore breakthrough research articles, reaction mechanisms, and innovative strategies in organic synthesis.

Research Articles

The Molecular LEGO Revolution: Building Complex Molecules with Electricity and Acid

Discover how electrocatalytic decarboxylative cross-coupling is revolutionizing complex molecule synthesis using electricity and readily available carboxylic acids.

Anna Long
Oct 27, 2025

The d³-Reagent: A Versatile Powerhouse in Organic Synthesis

Explore 3-Lithiopropyl tert-Butyl Thioether, a specialized γ-functionalised organolithium reagent revolutionizing molecular synthesis with unprecedented precision.

Lucas Price
Oct 26, 2025

The Silent Green Revolution: How Mechanochemistry is Reshaping Organometallic Synthesis

Explore how mechanochemistry is transforming organometallic synthesis through solvent-free methods, enabling sustainable chemistry and novel reactivities.

Ethan Sanders
Oct 23, 2025

A Safer Path to a Medical Marvel: Synthesizing Sulfathiazole in the Modern Lab

Explore the modern, safer laboratory synthesis of sulfathiazole, a revolutionary sulfonamide antibiotic with historical significance in medicine.

Connor Hughes
Oct 22, 2025

Nature's Deadly Secrets: The Chemical Art of Synthesizing Pederin and Psymberin

Exploring how chemists have mastered nature's blueprints through total synthesis of pederin and psymberin, opening new avenues for cancer drug discovery.

Levi James
Oct 20, 2025

The 1997 RSC Award in Synthetic Organic Chemistry: Recognizing Excellence

Exploring the 1997 RSC Award in Synthetic Organic Chemistry, its recipient P. Anthony G. M. Barrett, and the scientific context of this prestigious honor.

Brooklyn Rose
Oct 20, 2025

The Trimethylenemethane Cycloaddition: Taming a Wild Molecule for Synthesis

Explore the fascinating chemistry of trimethylenemethane cycloaddition, a powerful synthetic tool for constructing complex five-membered ring systems.

Violet Simmons
Oct 20, 2025

Crafting the Invisible: The Art and Science of Building Advanced Nanoparticles

Explore the fascinating world of nanoparticle synthesis and how scientists build these tiny powerhouses with astonishing precision.

Levi James
Oct 18, 2025

Pyrazoles: The Tiny Ring Powering Modern Medicine

Explore the chemistry, synthesis methods, and applications of pyrazoles - the powerful heterocyclic compounds revolutionizing modern medicine.

Connor Hughes
Oct 17, 2025

Building Molecular Masterpieces: The Catalytic Duo Revolutionizing Benzofuran Synthesis

Discover how copper(II) bromide and boron trifluoride etherate cocatalysis enables efficient benzofuran synthesis under mild conditions for pharmaceutical applications.

Emily Perry
Oct 15, 2025

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