Advanced Synthetic Methodologies

Explore breakthrough research articles, reaction mechanisms, and innovative strategies in organic synthesis.

Research Articles

Molecular Makeover: How Chemists Are Rewriting Molecules with Light and Metals

Explore the revolutionary technique of functional group transposition using palladium and photoredox dual catalysis for molecular editing.

Aaron Cooper
Nov 14, 2025

Chemistry's Digital Revolution: How Data Science Deciphers Organic Reactions

Explore how data science and AI are transforming organic chemistry, enabling real-time reaction analysis and predictive modeling of chemical processes.

Hunter Bennett
Nov 03, 2025

Taming the Tiny Spring: How Chemists Master the Shape of Molecules

Discover how chemists are mastering molecular shape through systematic study of cyclopropyl ketones and their stereoselective reduction.

Logan Murphy
Nov 01, 2025

The Alchemist's New Apprentice: When Test Tubes Meet Supercomputers

How the marriage of lab experiments and digital calculation is revolutionizing the creation of new matter in modern chemistry.

Grayson Bailey
Oct 31, 2025

Beyond Force: How Eric Jacobsen's Molecular Attraction is Reshaping Chemistry

Explore Eric N. Jacobsen's Arthur C. Cope Award-winning research on noncovalent catalysis and its transformative impact on chemical synthesis.

Grayson Bailey
Oct 28, 2025

Molecular Architects: How Chemists Remix the Elements to Forge New Materials

Explore how synthetic organic chemists control molecular behavior through coordination chemistry, substituent effects, and element substitution to create new materials.

Christian Bailey
Oct 27, 2025

Beyond Simple Bonds: The Power of Tandem Vicinal Difunctionalization

Explore the powerful technique of tandem vicinal difunctionalization in organic chemistry - adding two functional groups to adjacent carbon atoms in a single process.

Eli Rivera
Oct 25, 2025

The 1997 RSC Award in Synthetic Organic Chemistry: Recognizing Excellence

Exploring the 1997 RSC Award in Synthetic Organic Chemistry, its recipient P. Anthony G. M. Barrett, and the scientific context of this prestigious honor.

Brooklyn Rose
Oct 20, 2025

Molecular Surgery: The Art of Editing Nature's Most Reluctant Bonds

Discover how selective sp3 C–H alkylation via polarity-match-based cross-coupling is revolutionizing drug discovery and molecular design.

Abigail Russell
Oct 13, 2025

From Classroom to Cure: Crafting a Complex Molecule on a Student's Lab Bench

How a simple, four-step chemical recipe is revolutionizing how we teach and discover new medicines using only teaching lab equipment.

Charles Brooks
Oct 13, 2025

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