Research Articles
The Molecular Lego Kit: Building Complex Imidazoles with Precision and Speed
Discover how a new efficient synthesis method for 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted-1H-imidazoles is revolutionizing drug discovery.
The Silent Revolution in Medicine Creation: C–H Functionalization
Discover how C–H functionalization is revolutionizing drug discovery by enabling precise molecular modifications that accelerate medicine development.
Molecular Origami: Titanium's Precision Sculpting of New Medicines
Discover how titanium-catalyzed cyclopropanation is revolutionizing drug discovery through precise molecular sculpting of cyclopropane rings.
The DNA Library: How Tiny Tags Revolutionized the Hunt for New Medicines
Explore how DNA-encoded combinatorial chemical libraries are transforming drug discovery by enabling screening of billions of compounds simultaneously.
Crafting Molecular Master Keys: The Art of Building Bioactive Benzothiazoles
Explore how scientists synthesize C-2-substituted benzothiazoles, versatile molecules with promising biological activities including anti-cancer properties.
Tiny Molecular Cups Are Revolutionizing Drug Discovery
Discover how calix[4]arenes, bowl-shaped molecules, are transforming pharmaceutical synthesis through precise catalysis of oxygen- and nitrogen-containing rings.
The Hidden World of Indole Alkaloids: From Nature's Pharmacy to Scientific Breakthroughs
Explore the fascinating world of indole alkaloids - nature's complex medicines that form the backbone of treatments for cancer, hypertension, and malaria.
Unlocking Medicine's Next Frontier: The Chiral Fluorine Revolution
Discover how I(I)/I(III) catalysis is revolutionizing drug design by creating chiral fluorinated isosteres, expanding organofluorine chemical space for next-generation medicines.
The Handedness of Molecules: How Acid Catalysts are Revolutionizing Drug Discovery
Explore how chiral Brønsted acid catalysis is transforming drug discovery by enabling precise synthesis of single-enantiomer pharmaceuticals.
The Sulfur Revolution: Greener Paths to Life-Saving Molecules
Discover how sustainable thioamide synthesis is revolutionizing drug discovery for diseases like tuberculosis and COVID-19 through green chemistry approaches.